TRANSLATIONAL PHYSIOLOGY Hyperfiltration and effect of nitric oxide inhibition on renal and endothelial function in humans with uncomplicated type 1 diabetes mellitus
نویسندگان
چکیده
David Z. I. Cherney, Heather N. Reich, Shan Jiang, Ronnie Har, Rania Nasrallah, Richard L. Hébert, Vesta Lai, James W. Scholey,* and Etienne B. Sochett* Department of Medicine, Division of Nephrology and Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, Canada; Kidney Research Centre, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada; and Department of Pediatrics, Division of Endocrinology, The Hospital for Sick Children, University of Toronto, Canada
منابع مشابه
Hyperfiltration and effect of nitric oxide inhibition on renal and endothelial function in humans with uncomplicated type 1 diabetes mellitus.
Studies of experimental diabetes mellitus (DM) suggest that increased nitric oxide (NO) bioactivity contributes to renal hyperfiltration. However, the role of NO in mediating hyperfiltration has not been fully elucidated in humans. Our aim was to examine the effect of NO synthase inhibition on renal and peripheral vascular function in normotensive subjects with uncomplicated type 1 DM. Renal fu...
متن کاملRenal Hyperfiltration and Arterial Stiffness in Humans With Uncomplicated Type 1 Diabetes
OBJECTIVE We have reported that renal hyperfiltration is associated with endothelial dysfunction in early type 1 diabetes. However, the relationship between renal hyperfiltration and arterial stiffness is unknown. Accordingly, we measured arterial stiffness in type 1 diabetic subjects with hyperfiltering (n = 20) or normofiltering (n = 18). RESEARCH DESIGN AND METHODS Augmentation index (AIx)...
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OBJECTIVE Studies in animal models suggest that cyclooxygenase-2 (COX2) plays a role in the regulation of the renal microcirculation in diabetes. Accordingly, we examined the role of COX2 in the control of renal hemodynamic function and in the renal response to hyperglycemia in humans with uncomplicated type 1 diabetes. We hypothesized that COX2 inhibition would alleviate the hyperfiltration st...
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Diabetic nephropathy is the leading cause of end-stage renal disease in the Western hemisphere. Endothelial dysfunction is the central pathophysiologic denominator for all cardiovascular complications of diabetes including nephropathy. Abnormalities of nitric oxide (NO) production modulate renal structure and function in diabetes but, despite the vast literature, major gaps exist in our underst...
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Objective: Renal failure is a complication of diabetes. It can be the risk factor of cardiovascular disease. This study aimed to evaluate the effect of exercise course and Aloe-Vera supplementation on renal function and lipid profile in type 2 diabetes mellitus (T2DM) patients. Materials and Methods: This is a clinical trial double blind with pre-test and post hoc test analyses with a control ...
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تاریخ انتشار 2012